Reconstitution of human PDAC using primary cells reveals oncogenic transcriptomic features at tumor onset
Abstract Animal studies have demonstrated the ability of pancreatic acinar cells to transform into pancreatic ductal adenocarcinoma (PDAC).However, the tumorigenic Clear RP Parts potential of human pancreatic acinar cells remains under debate.To address this gap in knowledge, we expand sorted human acinar cells as 3D organoids and genetically modif